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If the choice is made to transform to Hydromorphone Hydrochloride Injection from An additional opioid analgesic utilizing publicly available data, convert The present full day by day amount of money(s) of opioid(s) gained to an equivalent whole each day dose of DILAUDID INJECTION and minimize by one particular-50 percent due to the opportunity of incomplete cross tolerance.
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Androgen deficiency: Cases of androgen deficiency have happened with usage of opioids for an prolonged length of time [see CLINICAL PHARMACOLOGY].
Hydromorphone wasn't mutagenic inside the in vitro bacterial reverse mutation assay (Ames assay). Hydromorphone was not clastogenic in either the in vitro human lymphocyte chromosome aberration assay or the in vivo mouse micronucleus assay.
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DILAUDID INJECTION incorporates sodium metabisulfite, a sulfite that may bring about allergic-sort reactions like anaphylactic signs or symptoms and everyday living-threatening or much less serious asthmatic episodes in specified vulnerable men and women.